Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence.

@article{Shibanuma1994CharacterizationOT,
  title={Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence.},
  author={Motoko Shibanuma and Jun‐ichi Mashimo and Toshio Kuroki and Kiyoshi Nose},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 43},
  pages={26767-74}
}
Transforming growth factor (TGF) beta 1 is a potent cytokine that inhibits the growth of several types of cells. Our earlier study suggested that the mouse osteoblastic cell line, MC3T3-E1, was sensitive to growth inhibition by TGF beta 1 and that this effect was partly mediated by H2O2. To identify the molecules that participate in the negative regulation of growth by these stimuli, we carried out differential screening of cDNA libraries and isolated a set of genes induced by TGF beta 1. Among… CONTINUE READING
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