Characterization of the Su antigen, a macromolecular complex of 100/102 and 200-kDa proteins recognized by autoantibodies in systemic rheumatic diseases.

@article{Satoh1994CharacterizationOT,
  title={Characterization of the Su antigen, a macromolecular complex of 100/102 and 200-kDa proteins recognized by autoantibodies in systemic rheumatic diseases.},
  author={M Satoh and Jenifer J. Langdon and Chen Hsi Chou and Daniel P. McCauliffe and Edward L Treadwell and Takashi Ogasawara and Michito Hirakata and Akira Suwa and Philip L. Cohen and Robert A. Eisenberg},
  journal={Clinical immunology and immunopathology},
  year={1994},
  volume={73 1},
  pages={
          132-41
        }
}
The Su autoantigen was characterized biochemically using human and murine autoimmune sera and the clinical significance of anti-Su antibodies was studied in 236 Japanese and 160 American patients with systemic rheumatic diseases. Anti-Su in immunodiffusion (ID) was strongly associated with immunoprecipitation of one or more 100- to 102-kDa proteins by MRL/lpr mouse sera (27/32 of ID positive vs 4/20 of ID negative, P = 0.000016), and all four human anti-Su reference sera immunoprecipitated the… CONTINUE READING

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