Characterization of the Stretch-activated Chloride Channel in Isolated Human Atrial Myocytes

  title={Characterization of the Stretch-activated Chloride Channel in Isolated Human Atrial Myocytes},
  author={Ryoichi Sato and S-i. Koumi},
  journal={The Journal of Membrane Biology},
Macroscopic and unitary currents through stretch-activated Cl− channels were examined in isolated human atrial myocytes using whole-cell, excised outside-out and inside-out configurations of the patch-clamp technique. When K+ and Ca2+ conductances were blocked and the intracellular Ca2+ concentration ([Ca2+] i ) was reduced, application of positive pressure via the pipette activated membrane currents under whole-cell voltage-clamp conditions. The reversal potential of the current shifted by 60… CONTINUE READING


Publications citing this paper.
Showing 1-9 of 9 extracted citations

Anion transport in heart.

View 5 Excerpts
Highly Influenced

Remodeling of atrial ATP-sensitive K⁺ channels in a model of salt-induced elevated blood pressure.

American journal of physiology. Heart and circulatory physiology • 2011
View 1 Excerpt

Cardiac adrenergic control and atrial fibrillation

Naunyn-Schmiedeberg's Archives of Pharmacology • 2009
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 39 references

Chloride conductance in human atrial cells.

Journal of molecular and cellular cardiology • 1995
View 4 Excerpts
Highly Influenced

Characterization of the inwardly-rectifying K channel in human cardiac myocytes: Alterations in channel behavior in myocytes isolated from patients with idiopathic dilated cardiomyopathy

Koumi, S-i., C. L. Backer, C. E. Arentzen
Circulation 92:164–174 • 1995
View 2 Excerpts

bAdrenergic modulation of the inwardly-rectifying potassium channel in isolated human ventricular myocytes: Alteration in channel response to b-adrenergic stimulation in failing human hearts

Koumi, S-i., C. L. Backer, C. E. Arentzen, R. Sato
J. Clin. Invest. 96:2870–2881 • 1995
View 3 Excerpts

Similar Papers

Loading similar papers…