Characterization of the Streptococcus pneumoniae BgaC protein as a novel surface beta-galactosidase with specific hydrolysis activity for the Galbeta1-3GlcNAc moiety of oligosaccharides.

@article{Jeong2009CharacterizationOT,
  title={Characterization of the Streptococcus pneumoniae BgaC protein as a novel surface beta-galactosidase with specific hydrolysis activity for the Galbeta1-3GlcNAc moiety of oligosaccharides.},
  author={Jae Kap Jeong and Ohsuk Kwon and Yun mi Lee and Doo-Byoung Oh and Jungwoo Lee and Seonghun Kim and Eunhye Kim and Tu Nhat Le and Dong-Kwon Rhee and Hyun Kang},
  journal={Journal of bacteriology},
  year={2009},
  volume={191 9},
  pages={
          3011-23
        }
}
Streptococcus pneumoniae is a causative agent of high morbidity and mortality. Although sugar moieties have been recognized as ligands for initial contact with the host, only a few exoglycosidases have been reported to occur in S. pneumoniae. In this study, a putative beta-galactosidase, encoded by the bgaC gene of S. pneumoniae, was characterized for its enzymatic activity and virulence. The recombinant BgaC protein, expressed and purified from Escherichia coli, was found to have a highly… CONTINUE READING
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