Characterization of the Stat5 protease.

  title={Characterization of the Stat5 protease.},
  author={Caroline P. S. Lee and Flavia Piazza and Siska Brutsaert and Jason Valens and Inga Strehlow and Mark A. Jarosinski and Chris J. M. Saris and Christian Schindler},
  journal={The Journal of biological chemistry},
  volume={274 38},
Immature myeloid cells have been shown to transduce signals through a carboxyl-terminally truncated isoform of Stat5. This functionally distinct signal transducer and activator of transcription isoform is generated through a unique protein-processing event. Evaluation of numerous cell lines has determined that there is a direct correlation between the expression of truncated Stat5 and protease activity. Moreover, protease activity is found only in the myeloid and not in lymphoid progenitors. To… CONTINUE READING
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