Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus

@article{Tumpey2005CharacterizationOT,
  title={Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus},
  author={T. Tumpey and C. Basler and P. Aguilar and H. Zeng and A. Solórzano and D. Swayne and N. Cox and J. Katz and J. Taubenberger and P. Palese and A. Garc{\'i}a-Sastre},
  journal={Science},
  year={2005},
  volume={310},
  pages={77 - 80}
}
The pandemic influenza virus of 1918–1919 killed an estimated 20 to 50 million people worldwide. With the recent availability of the complete 1918 influenza virus coding sequence, we used reverse genetics to generate an influenza virus bearing all eight gene segments of the pandemic virus to study the properties associated with its extraordinary virulence. In stark contrast to contemporary human influenza H1N1 viruses, the 1918 pandemic virus had the ability to replicate in the absence of… Expand
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