Characterization of the Plasmodium Interspersed Repeats (PIR) proteins of Plasmodium chabaudi indicates functional diversity

@inproceedings{Yam2016CharacterizationOT,
  title={Characterization of the Plasmodium Interspersed Repeats (PIR) proteins of Plasmodium chabaudi indicates functional diversity},
  author={Xue Yan Yam and Thibaut Brugat and Anthony Siau and Jennifer L. Lawton and Daniel S. Wong and Abdirahman Farah and Jing Shun Twang and Xiaohong Gao and Jean Langhorne and Peter Rainer Preiser},
  booktitle={Scientific reports},
  year={2016}
}
Plasmodium multigene families play a central role in the pathogenesis of malaria. The Plasmodium interspersed repeat (pir) genes comprise the largest multigene family in many Plasmodium spp. However their function(s) remains unknown. Using the rodent model of malaria, Plasmodium chabaudi, we show that individual CIR proteins have differential localizations within infected red cell (iRBC), suggesting different functional roles in a blood-stage infection. Some CIRs appear to be located on the… CONTINUE READING
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