Characterization of the PcCdc42 small G protein from Pneumocystis carinii, which interacts with the PcSte20 life cycle regulatory kinase.

@article{Krajicek2010CharacterizationOT,
  title={Characterization of the PcCdc42 small G protein from Pneumocystis carinii, which interacts with the PcSte20 life cycle regulatory kinase.},
  author={Bryan J. Krajicek and Theodore J. Kottom and Leah R. Villegas and Andrew H. Limper},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2010},
  volume={298 2},
  pages={
          L252-60
        }
}
Pneumocystis carinii (Pc) causes severe pneumonia in immunocompromised hosts. The binding of Pc trophic forms to alveolar epithelial cells is a central feature of infection, inducing the expression and activation of PcSte20, a gene participating in mating, proliferation, and pseudohyphal growth. In related fungi, Ste20 proteins are generally activated by immediate upstream small G proteins of the Cdc42-like family. PcCdc42 has not been previously described in Pneumocystis. To address the… CONTINUE READING

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