Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils

@article{Talpain1995CharacterizationOT,
  title={Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils},
  author={E. Talpain and R. Armstrong and R. A. Coleman and C. Vardey},
  journal={British Journal of Pharmacology},
  year={1995},
  volume={114}
}
1 The aims of this study were to characterize the EP receptor subtype mediating the inhibition of superoxide anion generation by formyl methionyl leucine phenylalanine (FMLP)‐stimulated human neutrophils, and to test the hypothesis that adenosine 3′:5′‐cyclic monophosphate (cyclic AMP) is the second messenger mediating the inhibition of the neutrophil by prostaglandin (PG)E2. 
Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP
Upon stimulation, neutrophils release their nuclear contents called neutrophil extracellular traps (NETs), which contain unfolded chromatin and lysosomal enzymes. NETs have been demonstrated to playExpand
Investigation of the inhibitory effects of PGE2 and selective EP agonists on chemotaxis of human neutrophils
  • R. Armstrong
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1995
TLDR
The hypothesis that cyclic AMP is the second messenger involved in prostaglandin E2‐stimulated human neutrophils is tested, and the inhibitory effects of selective EP agonists and type IV phosphodiesterase (PDE) inhibitors, rolipram and Ro20‐1724 have been examined. Expand
The inhibitory effect of prostaglandin E2 on rat neutrophil aggregation
  • H. Wise
  • Biology, Medicine
  • Journal of leukocyte biology
  • 1996
TLDR
Although PGE2 can stimulate [3H]cAMP production in neutrophils (EC50 4.3 10‐8 M), the anti‐aggregation response cannot be significantly attenuated by inhibitors of adenylate cyclase or protein kinase A, neither can it be potentiated by inhibition of phosphodiesterase activity. Expand
Prostaglandin E2 inhibits the phospholipase D pathway stimulated by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Involvement of EP2 receptors and phosphatidylinositol 3-kinase gamma.
TLDR
Examination of the effects of PGE(2) and prostaglandin E (EP) receptor-selective agonists/antagonists on several steps of the formyl-methionyl-leucyl-phenylalanine (fMLP)-induced phospholipase D (PLD) activation pathway in human neutrophils provides strong evidence that the inhibitory effects of FMLP-induced PLD activation pathway were mediated via EP( 2) receptors. Expand
Investigation of the role of nitric oxide and cyclic GMP in both the activation and inhibition of human neutrophils
TLDR
The finding that the guanylyl cyclase inhibitor LY 83583 completely inhibited chemotaxis and suppressed the maximal response suggests NO is a mediator of fMLP‐induced SAG, suggesting the paradox that NO both activates and inhibits human neutrophils is resolved. Expand
Differential sensitivity of macrophages to bradykinin
TLDR
The findings indicate that the stage of differentiation/maturation and activation of macrophages may be important for the ability of bradykinin to stimulate these cells to inflammatory responses in vivo. Expand
Histamine up-regulates phosphodiesterase 4 activity and reduces prostaglandin E2-inhibitory effects in human neutrophils
TLDR
Histamine up-regulates PDE4 activity and produces heterologous desensitisation of human neutrophils and reduced the inhibition by prostaglandin E2 of zymosan-induced superoxide generation. Expand
Role of Cyclooxygenase in the Chorionic Gonadotropin Regulation of Human Neutrophil Activity
TLDR
Data indicate that realization of the suppressive effects of chorionic gonadotropin in the neutrophils is partially linked with activation of cyclooxygenase (both the constitutive and inducible forms of the enzyme). Expand
The role of adenosine A2 receptors in the regulation of TNF-α production and PGE2 release in mouse peritoneal macrophages
TLDR
The results show that in this system, the inhibition of TNF-α release by adenosine is mediated by the A 2A receptors whereas the enhancement of PGE 2 release appears to be mediated byThe A 2B receptors. Expand
Activation of neutrophil-like HL-60 cells by prostaglandin E2.
  • H. Wise, Z. Xie
  • Chemistry, Medicine
  • Prostaglandins, leukotrienes, and essential fatty acids
  • 1996
TLDR
The aggregation response of HL-60 cells to PGE(2) was independent of extracellular calcium and did not involve mobilization of intracellular calcium, and inhibited the N-formyl-methionyl-leucyl-phenylalanine-stimulated increase in intrACEllular calcium in both neutrophils and HL- 60 cells. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
Stimulus-dependent inhibition of superoxide generation by prostaglandins.
TLDR
The effect of PG on O2- production is dependent on the specific stimulator and an increased concentration of cAMP in activated PMN is by itself not sufficient to limit O2 - generation induced by all stimuli. Expand
Inhibition of the n-formylmethionyl-leucyl-phenylalanine induced respiratory burst in human neutrophils by adrenergic agonists and prostaglandins of the E series.
  • K. Wong, K. Freund
  • Chemistry, Medicine
  • Canadian journal of physiology and pharmacology
  • 1981
Exogenous prostaglandins E1 and E2 and L-isoproterenol potently inhibited the production of superoxide anions by human neutrophils activated in vitro by n-formylmethionyl-leucyl-phenylalanine (FMLP).Expand
PGD2 and its mimetic ZK 110.841 are potent inhibitors of receptor-mediated activation of human neutrophils.
TLDR
An effective inhibition of receptor-mediated (FMLP, PAF) PMN activation by PGD2 and its mimetic ZK 110.841 is demonstrated, suggesting either an inhibitory PGD 2 receptor on human PMN or action of PGD1 at the PGE receptor. Expand
Characterization of the inhibitory prostanoid receptors on human neutrophils
TLDR
The rank order of potency of EP‐receptor agonists suggest that theEP‐receptors are of the EP2‐subtype; these data indicate the presence of both inhibitory EP‐ and DP‐ receptors on the human neutrophil. Expand
Receptor-specific threshold effects of cyclic AMP are involved in the regulation of enzyme release and superoxide production from human neutrophils.
TLDR
The results suggest that superoxide production is more sensitive to regulation by cyclic AMP than enzyme release, the type of receptor occupied as well as the threshold level of cycling AMP attained are important to the regulation of enzyme release. Expand
Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea‐pig ileum
TLDR
It is felt that the preparation must be used with caution to ascertain the EP1 agonist or antagonist potencies of novel compounds, and that EP2‐receptors may be involved in the PGE action, in view of the marked effect of morphine on the contractile actions of misoprostol,11‐deoxy PGE2‐1‐alcohol, 11‐de oxygen PGE1 and butaprost. Expand
Comparison of the prostaglandin E (EP) receptor of human neutrophils and HL-60 cells differentiated with DMSO.
TLDR
The lack of other prostanoid receptors coupled to adenylate cyclase in HL-60 cells suggests that these cells may provide a useful starting point for the cloning of the EP2 receptor. Expand
The effect of six prostaglandins, prostacyclin and iloprost on generation of superoxide anions by human polymorphonuclear leukocytes stimulated by zymosan or formyl-methionyl-leucyl-phenylalanine.
TLDR
PGD2 and PGEs use a common basic mechanism for inhibition of the generation of O2- by PMNs activated with FMLP or zymosan, and PGD2 is most generously furnished with these properties. Expand
Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization.
TLDR
Adenosine occupies an A2 receptor on neutrophils to raise intracellular cAMP in synergy with occupancy of the FMLP receptor, and indicates that cAMP is not the second messenger for inhibition of O2- generation by adenosine and its analogues. Expand
Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function.
TLDR
The data suggest that granule movement and acid hydrolase release from leukocyte lysosomes requires intact microtubules and may be modulated by adrenergic and cholinergic agents which appear to provoke changes in concentrations of cyclic nucleotides. Expand
...
1
2
3
4
...