Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils

@article{Talpain1995CharacterizationOT,
  title={Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils},
  author={Elisabeth Talpain and Roma A. Armstrong and Robert A. Coleman and Christopher J. Vardey},
  journal={British Journal of Pharmacology},
  year={1995},
  volume={114}
}
1 The aims of this study were to characterize the EP receptor subtype mediating the inhibition of superoxide anion generation by formyl methionyl leucine phenylalanine (FMLP)‐stimulated human neutrophils, and to test the hypothesis that adenosine 3′:5′‐cyclic monophosphate (cyclic AMP) is the second messenger mediating the inhibition of the neutrophil by prostaglandin (PG)E2. 

Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP

Upon stimulation, neutrophils release their nuclear contents called neutrophil extracellular traps (NETs), which contain unfolded chromatin and lysosomal enzymes. NETs have been demonstrated to play

Investigation of the inhibitory effects of PGE2 and selective EP agonists on chemotaxis of human neutrophils

  • R. Armstrong
  • Biology, Medicine
    British journal of pharmacology
  • 1995
TLDR
The hypothesis that cyclic AMP is the second messenger involved in prostaglandin E2‐stimulated human neutrophils is tested, and the inhibitory effects of selective EP agonists and type IV phosphodiesterase (PDE) inhibitors, rolipram and Ro20‐1724 have been examined.

The inhibitory effect of prostaglandin E2 on rat neutrophil aggregation

  • H. Wise
  • Biology
    Journal of leukocyte biology
  • 1996
TLDR
Although PGE2 can stimulate [3H]cAMP production in neutrophils (EC50 4.3 10‐8 M), the anti‐aggregation response cannot be significantly attenuated by inhibitors of adenylate cyclase or protein kinase A, neither can it be potentiated by inhibition of phosphodiesterase activity.

Prostaglandin E2 inhibits the phospholipase D pathway stimulated by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Involvement of EP2 receptors and phosphatidylinositol 3-kinase gamma.

TLDR
Examination of the effects of PGE(2) and prostaglandin E (EP) receptor-selective agonists/antagonists on several steps of the formyl-methionyl-leucyl-phenylalanine (fMLP)-induced phospholipase D (PLD) activation pathway in human neutrophils provides strong evidence that the inhibitory effects of FMLP-induced PLD activation pathway were mediated via EP( 2) receptors.

Investigation of the role of nitric oxide and cyclic GMP in both the activation and inhibition of human neutrophils

TLDR
The finding that the guanylyl cyclase inhibitor LY 83583 completely inhibited chemotaxis and suppressed the maximal response suggests NO is a mediator of fMLP‐induced SAG, suggesting the paradox that NO both activates and inhibits human neutrophils is resolved.

Differential sensitivity of macrophages to bradykinin

TLDR
The findings indicate that the stage of differentiation/maturation and activation of macrophages may be important for the ability of bradykinin to stimulate these cells to inflammatory responses in vivo.

Histamine up-regulates phosphodiesterase 4 activity and reduces prostaglandin E2-inhibitory effects in human neutrophils

TLDR
Histamine up-regulates PDE4 activity and produces heterologous desensitisation of human neutrophils and reduced the inhibition by prostaglandin E2 of zymosan-induced superoxide generation.

Role of Cyclooxygenase in the Chorionic Gonadotropin Regulation of Human Neutrophil Activity

TLDR
Data indicate that realization of the suppressive effects of chorionic gonadotropin in the neutrophils is partially linked with activation of cyclooxygenase (both the constitutive and inducible forms of the enzyme).

Activation of neutrophil-like HL-60 cells by prostaglandin E2.

  • H. WiseZ. Xie
  • Biology, Medicine
    Prostaglandins, leukotrienes, and essential fatty acids
  • 1996
...

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