Characterization of the N-methyltransferase activities of the multifunctional polypeptide cyclosporin synthetase.

Abstract

This study demonstrates a critical role for N-methylation in cyclosporin biosynthesis and maintenance of the biologically active cyclosporin conformation. The structural requirements for the AdoMet binding to CySyn were defined. N-methylation of specific amide positions in the cyclosporin backbone is critical for the complete assembly and cyclization of the… (More)
DOI: 10.1016/j.chembiol.2011.01.017

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@article{Velkov2011CharacterizationOT, title={Characterization of the N-methyltransferase activities of the multifunctional polypeptide cyclosporin synthetase.}, author={Tony Velkov and James Geoffrey Horne and Martin J Scanlon and Ben Capuano and Elizabeth Yuriev and Alfons Lawen}, journal={Chemistry & biology}, year={2011}, volume={18 4}, pages={464-75} }