Characterization of the M1(Ala213) type of alpha 1-antitrypsin, a newly recognized, common "normal" alpha 1-antitrypsin haplotype.

@article{Nukiwa1987CharacterizationOT,
  title={Characterization of the M1(Ala213) type of alpha 1-antitrypsin, a newly recognized, common "normal" alpha 1-antitrypsin haplotype.},
  author={Toshihiro Nukiwa and Mark L. Brantly and F Ogushi and Gerald A. Fells and Kouhei Satoh and Lori Stier and Michael Courtney and Ronald G. Crystal},
  journal={Biochemistry},
  year={1987},
  volume={26 17},
  pages={5259-67}
}
alpha 1-Antitrypsin (alpha 1AT) is a highly pleomorphic 52-kDa serum glycoprotein that functions as the major inhibitor of neutrophil elastase. Of these, the most common normal alpha 1AT haplotypes identified by isoelectric focusing (IEF) of serum are those of the M family, including M1, M2, and M3. In the course of studying the alpha 1AT type Z gene, we identified a restriction endonuclease BstEII polymorphism in the M1 gene that predicted the existence of a previously unidentified, but… CONTINUE READING