Characterization of the Kaposi's sarcoma-associated herpesvirus K1 signalosome.

  title={Characterization of the Kaposi's sarcoma-associated herpesvirus K1 signalosome.},
  author={Bok-Soo Lee and S Lee and Pinghui Feng and Heesoon Chang and Nam-Hyuk Cho and Jae U Jung},
  journal={Journal of virology},
  volume={79 19},
Kaposi's sarcoma (KS) is a multifocal angiogenic tumor and appears to be a hyperplastic disorder caused, in part, by local production of inflammatory cytokines. The K1 lymphocyte receptor-like protein of KS-associated herpesvirus (KSHV) efficiently transduces extracellular signals to elicit cellular activation events through its cytoplasmic immunoreceptor tyrosine-based activation motif (ITAM). To further delineate K1-mediated signal transduction, we purified K1 signaling complexes and… CONTINUE READING
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