Characterization of the Inflammatory Response in a Photothrombotic Stroke Model by MRI: Implications for Stem Cell Transplantation

@article{Vandeputte2010CharacterizationOT,
  title={Characterization of the Inflammatory Response in a Photothrombotic Stroke Model by MRI: Implications for Stem Cell Transplantation},
  author={Caroline Vandeputte and Debby Thomas and Tom Dresselaers and Annelies Crabbe and Catherine M. Verfaillie and Veerle Baekelandt and Koen Van Laere and Uwe Himmelreich},
  journal={Molecular Imaging and Biology},
  year={2010},
  volume={13},
  pages={663-671}
}
The aim of this study was to evaluate the specificity of magnetic resonance imaging (MRI) contrast in a photothrombotic (PT) stroke model with and without engraftment of superparamagnetic iron oxide (SPIO)-labeled stem cells. We monitored animals with PT stroke versus animals with PT stroke and stem cell engraftment by T2/T2*w MRI 4–8 h and 2, 4, 6/7 and 14 days after PT induction. Results were correlated with immunohistochemistry. T2*w MRI images showed hypointense contrast due to the… CONTINUE READING
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