Characterization of the Human Papillomavirus 16 E8 Promoter

@article{Straub2015CharacterizationOT,
  title={Characterization of the Human Papillomavirus 16 E8 Promoter},
  author={Elke Straub and Jasmin Fertey and Marcel Dreer and Thomas Iftner and Frank Stubenrauch},
  journal={Journal of Virology},
  year={2015},
  volume={89},
  pages={7304 - 7313}
}
ABSTRACT Persistent infections with certain human papillomaviruses (HPV) such as HPV16 are a necessary risk factor for the development of anogenital and oropharyngeal cancers. HPV16 genomes replicate as low-copy-number plasmids in the nucleus of undifferentiated keratinocytes, which requires the viral E1 and E2 replication proteins. The HPV16 E8^E2C (or E8^E2) protein limits genome replication by repressing both viral transcription and the E1/E2-dependent DNA replication. How E8^E2C expression… 
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