Characterization of the Hog1 MAPK pathway in the entomopathogenic fungus Beauveria bassiana.

@article{Liu2017CharacterizationOT,
  title={Characterization of the Hog1 MAPK pathway in the entomopathogenic fungus Beauveria bassiana.},
  author={Jing ai Liu and Zhi-kang Wang and Huan-huan Sun and Sheng-Hua Ying and Ming-Guang Feng},
  journal={Environmental microbiology},
  year={2017},
  volume={19 5},
  pages={
          1808-1821
        }
}
High-osmolarity glycerol (HOG) pathway required for yeast osmoregulation relies upon the mitogen-activated protein kinase (MAPK) Hog1 cascade that comprise the MAPKKKs Ssk2/Ssk22 and Ste11 converging on the MAPKK Pbs2. Here we show a Hog1 cascade with the unique MAPKKK Ssk2 acting in Beauveria bassiana. Hypersensitivity to high osmolarity and high resistance to fludioxonil fungicide appeared in Δssk2, Δpbs2 and Δhog1 mutants whereas the two hallmark phenotypes were reversed in Δste11. Increased… CONTINUE READING

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