Characterization of the Helicobacter pylori NikR-P(ureA) DNA interaction: metal ion requirements and sequence specificity.

HPNikR, a prokaryotic nickel binding transcription factor, is found in Helicobacter pylori where it functions as a regulator of multiple genes, including those involved in acid adaptation and nickel ion homeostasis. Particularly important is HPNikR's role in the regulation of the nickel-dependent enzyme urease which is critical for the organism's survival… (More)