Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function

Abstract

Central to the fully competent replication cycle of the human immunodeficiency virus type 1 (HIV-1) is the nuclear export of unspliced and partially spliced RNAs mediated by the Rev posttranscriptional activator and the Rev response element (RRE). Here, we introduce a novel method to explore the proteome associated with the nuclear HIV-1 RNAs. At the core… (More)
DOI: 10.1186/1742-4690-8-60

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