Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans.

@article{Frey2008CharacterizationOT,
  title={Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans.},
  author={Ulrich Hermann Frey and Wolfgang Lieb and Jeanette Erdmann and Danai Savidou and Gerd Heusch and Kirsten Leineweber and Heinz Jakob and H. -W. Hense and H. L{\"o}wel and Norbert H. Brockmeyer and Heribert Schunkert and Winfried Siffert},
  journal={European heart journal},
  year={2008},
  volume={29 7},
  pages={888-97}
}
AIMS Transgenic mice with cardiac overexpression of Gq develop cardiac hypertrophy, apoptosis, and heart failure. Similar mechanisms may contribute to human left ventricular hypertrophy (LVH). However, mechanisms regulating transcription of the human GNAQ gene encoding the Gq protein are unknown and single-nucleotide polymorphisms have not been reported. METHODS AND RESULTS We delineated essential elements for transcription in the human GNAQ promoter using reporter assays and showed promoter… CONTINUE READING

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