Characterization of the Francisella tularensis subsp. novicida type IV pilus.

@article{Zogaj2008CharacterizationOT,
  title={Characterization of the Francisella tularensis subsp. novicida type IV pilus.},
  author={Xhavit Zogaj and Subhra Chakraborty and Jirong Liu and David G Thanassi and Karl Klose},
  journal={Microbiology},
  year={2008},
  volume={154 Pt 7},
  pages={
          2139-50
        }
}
Francisella tularensis causes the disease tularaemia. Type IV pili (Tfp) genes are present in the genomes of all F. tularensis subspecies. We show that the wild-type F. tularensis subsp. novicida expresses pilus fibres on its surface, and mutations in the Tfp genes pilF and pilT disrupt pilus biogenesis. Mutations in other Tfp genes (pilQ and pilG) do not eliminate pilus expression. A mutation in pilE4 eliminates pilus expression, whereas mutations in the other pilin subunits pilE1-3 and pilE5… CONTINUE READING

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