Characterization of the FKBP.rapamycin.FRB ternary complex.

@article{Banaszynski2005CharacterizationOT,
  title={Characterization of the FKBP.rapamycin.FRB ternary complex.},
  author={Laura A. Banaszynski and Corey W. Liu and Thomas J. Wandless},
  journal={Journal of the American Chemical Society},
  year={2005},
  volume={127 13},
  pages={
          4715-21
        }
}
Rapamycin is an important immunosuppressant, a possible anticancer therapeutic, and a widely used research tool. Essential to its various functions is its ability to bind simultaneously to two different proteins, FKBP and mTOR. Despite its widespread use, a thorough analysis of the interactions between FKBP, rapamycin, and the rapamycin-binding domain of mTOR, FRB, is lacking. To probe the affinities involved in the formation of the FKBP.rapamycin.FRB complex, we used fluorescence polarization… CONTINUE READING
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