Characterization of the Early Lesion of ‘Degenerative’ Valvular Aortic Stenosis: Histological and Immunohistochemical Studies

@article{Otto1994CharacterizationOT,
  title={Characterization of the Early Lesion of ‘Degenerative’ Valvular Aortic Stenosis: Histological and Immunohistochemical Studies},
  author={Catherine M. Otto and Johanna Kuusisto and Dennis D. Reichenbach and Allen M. Gown and Kevin D. O’Brien},
  journal={Circulation},
  year={1994},
  volume={90},
  pages={844–853}
}
BackgroundNonrheumatic stenosis of trileaflet aortic valves, often termed senile or calcific valvular aortic stenosis, is considered a “degenerative” process, but little is known about the cellular or molecular factors that mediate its development. Methods and ResultsTo characterize the developing aortic valvular lesion, we performed histological and immunohisto-chemical studies on Formalin-fixed and methanol-Carnoy's-fixed parafflin-embedded aortic valve leaflets or on frozen sections obtained… 

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