Characterization of the E138K resistance mutation in HIV-1 reverse transcriptase conferring susceptibility to etravirine in B and non-B HIV-1 subtypes.

@article{Asahchop2011CharacterizationOT,
  title={Characterization of the E138K resistance mutation in HIV-1 reverse transcriptase conferring susceptibility to etravirine in B and non-B HIV-1 subtypes.},
  author={Eugene Lekeawung Asahchop and Maureen Oliveira and Mark A. Wainberg and Bluma G Brenner and Daniela D Moisi and Thomas d'Aquin Toni and C{\'e}cile L Tremblay},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 2},
  pages={600-7}
}
We have selected for resistance to etravirine (ETR) and efavirenz (EFV) in tissue culture using three subtype B, three subtype C, and two CRF02_AG clinical isolates, grown in cord blood mononuclear cells. Genotypic analysis was performed at baseline and at various weeks of selection. Phenotypic resistance in regard to ETR, EFV, and nevirapine (NVP) was evaluated at weeks 25 to 30 for all ETR-selected viruses and in viral clones that contained specific resistance mutations that were inserted by… CONTINUE READING

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