Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4.

  title={Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4.},
  author={Marie-Chlo{\'e} Boulanger and Tina Branscombe Miranda and Steven Clarke and Marco Di Fruscio and Beat Suter and Paul Lasko and St{\'e}phane Richard},
  journal={The Biochemical journal},
  volume={379 Pt 2},
The role of arginine methylation in Drosophila melanogaster is unknown. We identified a family of nine PRMTs (protein arginine methyltransferases) by sequence homology with mammalian arginine methyltransferases, which we have named DART1 to DART9 ( Drosophila arginine methyltransferases 1-9). In keeping with the mammalian PRMT nomenclature, DART1, DART4, DART5 and DART7 are the putative homologues of PRMT1, PRMT4, PRMT5 and PRMT7. Other DART family members have a closer resemblance to PRMT1… CONTINUE READING

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