Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.

@article{Grossberger1999CharacterizationOT,
  title={Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.},
  author={Rupert Grossberger and Christian Gieffers and W. Zachariae and Alexandre V. Podtelejnikov and Alexander Schleiffer and Kim Nasmyth and Matthias Mann and Jeffrey M Peters},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 20},
  pages={
          14500-7
        }
}
The anaphase-promoting complex/cyclosome (APC) is a ubiquitin-protein ligase whose activity is essential for progression through mitosis. The vertebrate APC is thought to be composed of 8 subunits, whereas in budding yeast several additional APC-associated proteins have been identified, including a 33-kDa protein called Doc1 or Apc10. Here, we show that Doc1/Apc10 is a subunit of the yeast APC throughout the cell cycle. Mutation of Doc1/Apc10 inactivates the APC without destabilizing the… CONTINUE READING

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