Characterization of the 5-hydroxymethylcytosine-specific DNA restriction endonucleases

@inproceedings{Borgaro2013CharacterizationOT,
  title={Characterization of the 5-hydroxymethylcytosine-specific DNA restriction endonucleases},
  author={Janine G. Borgaro and Zhenyu Zhu},
  booktitle={Nucleic acids research},
  year={2013}
}
In T4 bacteriophage, 5-hydroxymethylcytosine (5hmC) is incorporated into DNA during replication. In response, bacteria may have developed modification-dependent type IV restriction enzymes to defend the cell from T4-like infection. PvuRts1I was the first identified restriction enzyme to exhibit specificity toward hmC over 5-methylcytosine (5mC) and cytosine. By using PvuRts1I as the original member, we identified and characterized a number of homologous proteins. Most enzymes exhibited similar… CONTINUE READING

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