Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocation.

@article{Panagopoulos1994CharacterizationOT,
  title={Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocation.},
  author={Ioannis Panagopoulos and Nils Mandahl and David Ron and Mattias H{\"o}glund and Mef Nilbert and Fredrik Mertens and Felix Mitelman and Pierre Aman},
  journal={Cancer research},
  year={1994},
  volume={54 24},
  pages={6500-3}
}
Myxoid liposarcomas are cytogenetically characterized by t(12;16)(q13;p11). The translocation results in rearrangements of the CHOP gene in 12q13 and the FUS gene in 16p11, creating a fusion gene where the RNA-binding domain of FUS is replaced by the DNA-binding and leucine zipper dimerization domain of CHOP. In the present study, we have mapped 16 genomic breakpoints in the region of the CHOP gene and isolated and sequenced a new variant (type II) of the chimeric FUS/CHOP transcript. The… CONTINUE READING
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