Characterization of the C-terminal domain of Helicobacter pylori vacuolating toxin and its relationship with extracellular toxin production.

@article{Wang1998CharacterizationOT,
  title={Characterization of the C-terminal domain of Helicobacter pylori vacuolating toxin and its relationship with extracellular toxin production.},
  author={Horng-Dar Wang and Poa C Chang and C H Kuo and Chyng Shyan Tzeng and Wei Cheng Wang},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={250 2},
  pages={397-402}
}
Helicobacter pylori vacuolating cytotoxin (VacA) induces gastric epithelial necrosis. Its C-terminal domain is hypothesized to be responsible for extracellular translocation of the mature cytotoxin. In this study, genetic-structural properties of VacA C-terminal domain and the level of cytotoxin secretion were investigated. Sau3AI-HaeIII restriction… CONTINUE READING