Characterization of the Biochemical Properties and Biological Function of the Formin Homology Domains of Drosophila DAAM*

@inproceedings{Bark2010CharacterizationOT,
  title={Characterization of the Biochemical Properties and Biological Function of the Formin Homology Domains of Drosophila DAAM*},
  author={Szilvia Bark{\'o} and Be{\'a}ta Bugyi and M. Carlier and Rita Gombos and Tam{\'a}s Matusek and J{\'o}zsef Mih{\'a}ly and Mikl{\'o}s Nyitrai},
  booktitle={The Journal of biological chemistry},
  year={2010}
}
We characterized the properties of Drosophila melanogaster DAAM-FH2 and DAAM-FH1-FH2 fragments and their interactions with actin and profilin by using various biophysical methods and in vivo experiments. The results show that although the DAAM-FH2 fragment does not have any conspicuous effect on actin assembly in vivo, in cells expressing the DAAM-FH1-FH2 fragment, a profilin-dependent increase in the formation of actin structures is observed. The trachea-specific expression of DAAM-FH1-FH2… CONTINUE READING

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