Characterization of the Aspergillus fumigatus phosphomannose isomerase Pmi1 and its impact on cell wall synthesis and morphogenesis.

@article{Fang2009CharacterizationOT,
  title={Characterization of the Aspergillus fumigatus phosphomannose isomerase Pmi1 and its impact on cell wall synthesis and morphogenesis.},
  author={Wenxia Fang and Xiaoying Yu and Bin Wang and Hui Zhou and Haomiao Ouyang and Jia Ming and Cheng Jin},
  journal={Microbiology},
  year={2009},
  volume={155 Pt 10},
  pages={3281-93}
}
Phosphomannose isomerase (PMI) is an enzyme catalysing the interconversion of mannose 6-phosphate (Man-6-P) and fructose 6-phosphate (Fru-6-P). The reaction catalysed by PMI is the first committed step in the synthesis of mannose-containing sugar chains and provides a link between glucose metabolism and mannosylation. In this study, the pmi1 gene was identified to encode PMI in the human fungal pathogen Aspergillus fumigatus. Characterization of A. fumigatus Pmi1 expressed in Escherichia coli… CONTINUE READING