Characterization of the Antinociceptive Actions of Bicifadine in Models of Acute, Persistent, and Chronic Pain

@article{Basile2007CharacterizationOT,
  title={Characterization of the Antinociceptive Actions of Bicifadine in Models of Acute, Persistent, and Chronic Pain},
  author={A. Basile and A. Janowsky and K. Gołembiowska and M. Kowalska and E. Tam and M. Benveniste and P. Popik and A. Nikiforuk and M. Krawczyk and G. Nowak and P. Krieter and A. Lippa and P. Skolnick and E. Koustova},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2007},
  volume={321},
  pages={1208 - 1225}
}
Bicifadine (1-p-tolyl-3-azabicyclo[3.1.0]hexane) inhibits monoamine neurotransmitter uptake by recombinant human transporters in vitro with a relative potency of norepinephrine > serotonin > dopamine (≈1:2:17). This in vitro profile is supported by microdialysis studies in freely moving rats, where bicifadine (20 mg/kg i.p.) increased extrasynaptic norepinephrine and serotonin levels in the prefrontal cortex, norepinephrine levels in the locus coeruleus, and dopamine levels in the striatum… Expand
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