Characterization of the 5-HT1B recognition site in rat brain: binding studies with (-)[125I]iodocyanopindolol.

@article{Hoyer1985CharacterizationOT,
  title={Characterization of the 5-HT1B recognition site in rat brain: binding studies with (-)[125I]iodocyanopindolol.},
  author={Daniel Hoyer and G{\"u}nther Engel and Hans Otto Kalkman},
  journal={European journal of pharmacology},
  year={1985},
  volume={118 1-2},
  pages={
          1-12
        }
}
“5-HT1R” or 5-HT1D sites? Evidence for 5-HT 1D binding sites in rabbit brain
TLDR
The present data strongly suggest that rabbit brain has recognition sites with the pharmacological profile and distribution characteristic of the 5-HT1D recognition site and are in agreement with results obtained by Limberger et al. (1991).
Characterization of rat cerebral cortical beta adrenoceptor subtypes using (-)-[125I]-iodocyanopindolol.
TLDR
It is concluded that since (-)ICYP binds to both beta adrenoceptors and serotonin receptors, it is important to prevent the binding of (-) ICYP to serotonin receptors by adding a suppressing ligand like excess cold serotonin when assaying beta adrenOceptors.
Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain
TLDR
The regional distribution and the pharmacology of the binding sites labelled with the novel 5-hydroxytryptamine (serotonin) 5-HT1B/1D selective radioligand serotonin-O-carboxy-methyl-glycyl-[125I]tyrosinamide (abbreviated [ 125I]GTI) was determined using quantitative autoradiography in rat brain.
[3H]Ketanserin labels 5-HT2 receptors and α1-adrenoceptors in human and pig brain membranes
TLDR
It is demonstrated that [3H]ketanserin in nanomolar concentrations binds significantly to α1-adrenoceptors in human and pig frontal cortex membranes; this suggests a rather limited degree of selectivity of ketanserserin for 5-HT2 receptors in pig and human tissues.
Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites
TLDR
In rat brain cortex slices preincubated with [3H]5-HT, the evidence indicates that the presynaptic 5- HT autoreceptor belongs to the 5-HT1B receptor subtype.
Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes
  • R. E. Heuring, S. Peroutka
  • Biology, Chemistry
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1987
TLDR
The data demonstrate the presence of a homogeneous class of 5- HT1 binding sites in bovine caudate that is pharmacologically distinct from previously defined 5-HT1A, 5-ht1B, 5 - HT1C, 4-HT2, 3-HT3 receptor subtypes.
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TLDR
It is concluded that constrictor responses to 5-HT of canine basilar artery are mediated by5-HT2-like receptors, and the agonist potencies of 8 indole derivatives and the potency of 19 recognized antagonists to inhibit constrictors' responses were established.
Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT
TLDR
3H-PAT seems to be a useful ligand for studying the biochemical and pharmacological characteristics of presynaptic autoreceptors in selected regions of rat brain.
Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.
TLDR
It is proposed that [3H]5-HT and[3H]-spiroperidol label distinct populations of serotonin receptors in rat brain, designated 5-HT1 and 5- HT2 receptors, respectively.
Discrimination of Multiple [3H]5‐Hydroxytryptamine Binding Sites by the Neuroleptic Spiperone in Rat Brain
TLDR
Saturation studies of [3H]5‐HT binding assayed in the absence or presence of 1 μM‐spiperone reveal a parallel shift in the Scatchard plot with no change in the dissociation constant of [2‐12 nM], but a significant decrease in the number of specific binding sites.
2-[125Iodo]LSD, a new ligand for the characterisation and localisation of 5-HT2 receptors
TLDR
125IOL was employed for the autoradiographic localisation of its binding sites after in vitro labelling of microtome rat brain sections and it can be concluded that the sites labelled by 125IOL have pharmacological properties in common with central 5HT2 receptors, which are identical with vascular postjunctional 5HT receptors.
Identification of 5HT2-receptors on longitudinal muscle of the guinea pig ileum.
TLDR
It is concluded that the ileum contains postjunctional 5HT2-receptors which mediate contraction and the nature of the ILSD binding sites in the ilesum remains to be elucidated.
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