Characterization of the 5'-flanking fragment of the human GM3-synthase gene.

  title={Characterization of the 5'-flanking fragment of the human GM3-synthase gene.},
  author={Guichao Zeng and Luoyi Gao and Tian Xia and Tewin Tencomnao and Robert K. Yu},
  journal={Biochimica et biophysica acta},
  volume={1625 1},
To investigate the transcriptional regulation of human GM3-synthase, a 5'-flanking fragment of 1379 bp was cloned by a PCR-based procedure. Analysis of the human genomic sequence showed that the gene consists of seven exons, locates at chromosome 2, and spans over 62 kb. There are a number of potential consensus binding sites in the cloned promoter region, but TATA and CCAAT boxes were not found in the promoter. Primer extension analysis identified two transcription start sites approximately 11… CONTINUE READING
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