Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 2. Behavioral and cognitive changes

@article{Sterniczuk2010CharacterizationOT,
  title={Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 2. Behavioral and cognitive changes},
  author={Roxanne Sterniczuk and Michael C Antle and Frank M. Laferla and Richard H Dyck},
  journal={Brain Research},
  year={2010},
  volume={1348},
  pages={149-155}
}
  • Roxanne Sterniczuk, Michael C Antle, +1 author Richard H Dyck
  • Published in Brain Research 2010
  • Psychology, Medicine
  • Alzheimer's disease (AD) is characterized by distinct behavioral and cognitive deficits that differ from those observed in normal aging. Transgenic models of AD are a promising tool in understanding the underlying mechanisms and cause of disease. The triple-transgenic mouse model of AD (3xTg-AD) is the only model to exhibit both Abeta and tau pathology that is characteristic of the human form. The present study characterized the performance of 3xTg-AD mice on several tasks measuring behavioral… CONTINUE READING

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