Characterization of the 2A7 antigen as a 85-kDa human nucleocytoplasmic shuttling protein.

@article{PaulinLevasseur1999CharacterizationOT,
  title={Characterization of the 2A7 antigen as a 85-kDa human nucleocytoplasmic shuttling protein.},
  author={Micheline Paulin-Levasseur and Marion Julien},
  journal={Experimental cell research},
  year={1999},
  volume={250 2},
  pages={439-51}
}
The murine monoclonal antibody 2A7 was found to react specifically with a 85-kDa human protein which is distributed throughout the nuclear interior in interphase and becomes associated with condensed chromosomes during mitosis. The 2A7 epitope was not detected in cells from other species. Two-dimensional immunoblotting analysis of HeLa cell homogenates further indicated that the 85-kDa polypeptide species recognized by the 2A7 antibody corresponds to an acidic protein which may be complexed in… CONTINUE READING

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