Characterization of the 26S proteasome network in Plasmodium falciparum

@inproceedings{Wang2015CharacterizationOT,
  title={Characterization of the 26S proteasome network in Plasmodium falciparum},
  author={Lihui Wang and Claire Delahunty and Karin Fritz-Wolf and Stefan Rahlfs and Judith Helena Prieto and John R. Yates and Katja Becker},
  booktitle={Scientific reports},
  year={2015}
}
In eukaryotic cells, the ubiquitin-proteasome system as a key regulator of protein quality control is an excellent drug target. We therefore aimed to analyze the 26S proteasome complex in the malaria parasite Plasmodium falciparum, which still threatens almost half of the world's population. First, we established an affinity purification protocol allowing for the isolation of functional 26S proteasome complexes from the parasite. Subunit composition of the proteasome and component stoichiometry… CONTINUE READING
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