Characterization of the 1918 influenza virus polymerase genes

@article{Taubenberger2005CharacterizationOT,
  title={Characterization of the 1918 influenza virus polymerase genes},
  author={J. Taubenberger and A. Reid and Raina M. Lourens and R. Wang and G. Jin and T. Fanning},
  journal={Nature},
  year={2005},
  volume={437},
  pages={889-893}
}
  • J. Taubenberger, A. Reid, +3 authors T. Fanning
  • Published 2005
  • Medicine, Biology
  • Nature
  • The influenza A viral heterotrimeric polymerase complex (PA, PB1, PB2) is known to be involved in many aspects of viral replication and to interact with host factors, thereby having a role in host specificity. The polymerase protein sequences from the 1918 human influenza virus differ from avian consensus sequences at only a small number of amino acids, consistent with the hypothesis that they were derived from an avian source shortly before the pandemic. However, when compared to avian… CONTINUE READING

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