Characterization of the 1918 influenza virus polymerase genes

@article{Taubenberger2005CharacterizationOT,
  title={Characterization of the 1918 influenza virus polymerase genes},
  author={Jeffery K. Taubenberger and Ann H. Reid and Raina M. Lourens and Ruixue Wang and Guozhong Jin and Thomas G. Fanning},
  journal={Nature},
  year={2005},
  volume={437},
  pages={889-893}
}
The influenza A viral heterotrimeric polymerase complex (PA, PB1, PB2) is known to be involved in many aspects of viral replication and to interact with host factors, thereby having a role in host specificity. The polymerase protein sequences from the 1918 human influenza virus differ from avian consensus sequences at only a small number of amino acids, consistent with the hypothesis that they were derived from an avian source shortly before the pandemic. However, when compared to avian… 
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TLDR
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The origin and virulence of the 1918 "Spanish" influenza virus.
  • J. Taubenberger
  • Biology, Medicine
    Proceedings of the American Philosophical Society
  • 2006
TLDR
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