Characterization of the 1918 "Spanish" influenza virus neuraminidase gene.

  title={Characterization of the 1918 "Spanish" influenza virus neuraminidase gene.},
  author={Ann H. Reid and Thomas G. Fanning and Thomas A. Janczewski and Jeffery K. Taubenberger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 12},
The "Spanish" influenza pandemic of 1918 was characterized by exceptionally high mortality, especially among young adults. The surface proteins of influenza viruses, hemagglutinin and neuraminidase, play important roles in virulence, host specificity, and the human immune response. The complete coding sequence of hemagglutinin was reported last year. This laboratory has now determined the complete coding sequence of the neuraminidase gene of the 1918 virus. Influenza RNA fragments were isolated… CONTINUE READING
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