Characterization of the [2Fe-2S] cluster of Escherichia coli transcription factor IscR.

  title={Characterization of the [2Fe-2S] cluster of Escherichia coli transcription factor IscR.},
  author={Angela S. Fleischhacker and Audria Stubna and Kuang-Lung Hsueh and Yisong Guo and Sarah J. Teter and Justin C Rose and Thomas C Brunold and John L. Markley and Eckard M{\"u}nck and Patricia Kiley},
  volume={51 22},
IscR is an Fe-S cluster-containing transcription factor involved in a homeostatic mechanism that controls Fe-S cluster biogenesis in Escherichia coli. Although IscR has been proposed to act as a sensor of the cellular demands for Fe-S cluster biogenesis, the mechanism by which IscR performs this function is not known. In this study, we investigated the biochemical properties of the Fe-S cluster of IscR to gain insight into the proposed sensing activity. Mössbauer studies revealed that IscR… CONTINUE READING

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