Characterization of the "hygroscopic" properties of active pharmaceutical ingredients.

@article{Newman2008CharacterizationOT,
  title={Characterization of the "hygroscopic" properties of active pharmaceutical ingredients.},
  author={Ann W. Newman and Susan M Reutzel-Edens and George D Zografi},
  journal={Journal of pharmaceutical sciences},
  year={2008},
  volume={97 3},
  pages={1047-59}
}
The amount of water vapor taken up by an active pharmaceutical ingredient (API) as a function of relative humidity is routinely evaluated to characterize and monitor its "hygroscopicity" throughout the drug development process. In this minireview we address the necessity of going beyond the measurement of water vapor sorption isotherms to establish the… CONTINUE READING