Characterization of tertiary folding of RNA by circular dichroism and urea.

@article{Sosnick2001CharacterizationOT,
  title={Characterization of tertiary folding of RNA by circular dichroism and urea.},
  author={Tobin R. Sosnick},
  journal={Current protocols in nucleic acid chemistry},
  year={2001},
  volume={Chapter 11},
  pages={Unit 11.5}
}
CD spectroscopy can be used to monitor RNA tertiary folding transitions that may not be observable by absorbance spectroscopy. With the use of computer-controlled titrators, data can be acquired rapidly, and accurate thermodynamic properties can be obtained over a wide variety of conditions. Thus, CD spectroscopy provides a useful complement to site-resolved or chemical modification methods. 

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