Characterization of tau positron emission tomography tracer [18F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias.

@article{Sander2016CharacterizationOT,
  title={Characterization of tau positron emission tomography tracer [18F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias.},
  author={Kerstin Sander and Tammaryn Lashley and Priya Gami and Thibault Gendron and Mark F. Lythgoe and Jonathan D. Rohrer and Jonathan M. Schott and Tamas R Revesz and Nick C. Fox and Erik {\AA}rstad},
  journal={Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year={2016},
  volume={12 11},
  pages={1116-1124}
}
INTRODUCTION Aggregation of tau is a hallmark of many neurodegenerative diseases, and tau imaging with positron emission tomography (PET) may allow early diagnosis and treatment monitoring. We assessed binding of the PET tracer [18F]AV-1451 in a range of dementias. METHODS Phosphorimaging was used to quantify binding to postmortem brain tissue from 33 patients with different, histopathologically characterized, neurodegenerative dementias. RESULTS [18F]AV-1451 showed high specific binding in… CONTINUE READING
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