Characterization of tau fibrillization in vitro.

  title={Characterization of tau fibrillization in vitro.},
  author={Shaohua Xu and Kurt R. Brunden and John Q. Trojanowski and Virginia M-Y Lee},
  journal={Alzheimer's & dementia : the journal of the Alzheimer's Association},
  volume={6 2},
BACKGROUND The assembly of tau proteins into paired helical filaments, the building blocks of neurofibrillary tangles, is linked to neurodegeneration in Alzheimer's disease and related tauopathies. A greater understanding of this assembly process could identify targets for the discovery of drugs to treat Alzheimer's disease and related disorders. By using recombinant human tau, we have delineated events leading to the conversion of normal soluble tau into tau fibrils. METHODS Atomic force… CONTINUE READING