Characterization of tanshinones with quinone reductase induction activity from Radix Salvia miltiorrhiza by liquid chromatography/tandem mass spectrometry.

@article{Ma2009CharacterizationOT,
  title={Characterization of tanshinones with quinone reductase induction activity from Radix Salvia miltiorrhiza by liquid chromatography/tandem mass spectrometry.},
  author={Zhong-Jun Ma and Min Zhang and Zhihang Song},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2009},
  volume={23 18},
  pages={2857-66}
}
Quinone reductase (QR) induction is a reliable biomarker of phase II enzyme induction. In this study, glutathione (GSH) was employed and a liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was introduced to reveal the chemical constituents with QR activity from the ethyl acetate extract of roots Salvia miltiorrhiza ('Danshen') and nine tanshinones (9, 13, 17-19, 21, 24-26), which could conjugate with GSH, were characterized by LC/MS/MS and considered to have QR activities. Then… CONTINUE READING

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