Characterization of sumatriptan-induced contractions in human isolated blood vessels using selective 5-HT(1B) and 5-HT(1D) receptor antagonists and in situ hybridization.

@article{Broek2002CharacterizationOS,
  title={Characterization of sumatriptan-induced contractions in human isolated blood vessels using selective 5-HT(1B) and 5-HT(1D) receptor antagonists and in situ hybridization.},
  author={R{\'e}mon W M van den Broek and Pankaj Bhalla and A Massen VanDenBrink and Ren{\'e} de Vries and Hari Shanker Sharma and Pramod R. Saxena},
  journal={Cephalalgia : an international journal of headache},
  year={2002},
  volume={22 2},
  pages={83-93}
}
The 5-HT(1B/1D) receptor agonist sumatriptan is effective in aborting acute attacks of migraine and is known to cause constriction of cranial arteries as well as some peripheral blood vessels. The present study set out to investigate whether 5-HT(1B) and/or 5-HT(1D) receptors mediate contractions of the human isolated middle meningeal and temporal arteries (models for anti-migraine efficacy) and coronary artery and saphenous vein (models for side-effect potential). Concentration-response curves… CONTINUE READING

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