Characterization of sulfonylurea receptors and the action of potassium channel openers on cholinergic neurotransmission in guinea pig isolated small intestine.

@article{Zini1991CharacterizationOS,
  title={Characterization of sulfonylurea receptors and the action of potassium channel openers on cholinergic neurotransmission in guinea pig isolated small intestine.},
  author={S M Zini and Yehezkel Ben-Ari and Mike L.J. Ashford},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={259 2},
  pages={566-73}
}
Specific binding sites for [3H]glibenclamide, a potent ATP-sensitive K+ channel blocker, have been characterized in the isolated guinea pig longitudinal muscle-myenteric plexus preparation. The Scatchard plot of the saturation isotherm was curvilinear and revealed two binding sites, one of high affinity (Kd = 0.42 nM; maximum binding site = 156 fmol/mg of… CONTINUE READING