• Corpus ID: 26092861

Characterization of subtypes of alpha-2 adrenoceptors in the human brain.

@article{Ordway1993CharacterizationOS,
  title={Characterization of subtypes of alpha-2 adrenoceptors in the human brain.},
  author={Gregory A. Ordway and S M Jaconetta and Angelos Halaris},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={264 2},
  pages={
          967-76
        }
}
Radioligand binding studies have demonstrated that oxymetazoline has a high affinity for alpha-2A receptors, but lower affinities for alpha-2B and alpha-2C receptors. In contrast, prazosin has high affinity for alpha-2B and alpha-2C receptors, but relatively lower affinity for alpha-2A receptors. We exploited the respective selectivity of oxymetazoline and prazosin for alpha-2A and alpha-2B/2C adrenoceptors, respectively, to describe pharmacologically and to locate neuroanatomically alpha-2… 
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