Characterization of sputum biomarkers for asthma–COPD overlap syndrome

  title={Characterization of sputum biomarkers for asthma–COPD overlap syndrome},
  author={Jing Gao and Hiroshi Iwamoto and Jukka Koskela and Harri Alenius and Noboru Hattori and Nobuoki Kohno and Tarja Laitinen and Witold Mazur and Ville P Pulkkinen},
  booktitle={International journal of chronic obstructive pulmonary disease},
Asthma-COPD overlap syndrome (ACOS) is a commonly encountered chronic airway disease. However, ACOS is still a consensus-based clinical phenotype and the underlying inflammatory mechanisms are inadequately characterized. To clarify the inflammatory mediatypical for ACOS, five biomarkers, namely interleukin (IL)-13, myeloperoxidase (MPO), neutrophil gelatinase-associated lipocalin (NGAL), chitinase-like protein (YKL-40), and IL-6, were selected. This study hypothesized that sputum biomarkers… CONTINUE READING
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