Characterization of spontaneous excitatory synaptic currents in salamander retinal ganglion cells.

@article{Taylor1995CharacterizationOS,
  title={Characterization of spontaneous excitatory synaptic currents in salamander retinal ganglion cells.},
  author={William R Taylor and E Chen and David R. Copenhagen},
  journal={The Journal of physiology},
  year={1995},
  volume={486 ( Pt 1)},
  pages={207-21}
}
1. Spontaneous excitatory postsynaptic currents (sEPSCs) were recorded under voltage-clamp conditions. Consistent with activation of non-NMDA-type glutamate receptors, the sEPSCs reversed at potentials above 0 mV, were blocked by 1 microM CNQX and prolonged by 2 mM aniracetam. 2. The peak conductance of the averaged sEPSCs (n = 70-400) was 130 +/- 60 pS (mean +/- S.D.; 17 cells, ranging from 70 to 290 pS). Amplitude distributions were skewed towards larger amplitudes. 3. The decay of individual… CONTINUE READING

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