Characterization of spindle pole body duplication reveals a regulatory role for nuclear pore complexes

@inproceedings{Rthnick2017CharacterizationOS,
  title={Characterization of spindle pole body duplication reveals a regulatory role for nuclear pore complexes},
  author={Diana R{\"u}thnick and Annett Neuner and Franziska Dietrich and Daniel Kirrmaier and Ulrike Engel and Michael Knop and Elmar Schiebel},
  booktitle={The Journal of cell biology},
  year={2017}
}
The spindle pole body (SPB) of budding yeast duplicates once per cell cycle. In G1, the satellite, an SPB precursor, assembles next to the mother SPB (mSPB) on the cytoplasmic side of the nuclear envelope (NE). How the growing satellite subsequently inserts into the NE is an open question. To address this, we have uncoupled satellite growth from NE insertion. We show that the bridge structure that separates the mSPB from the satellite is a distance holder that prevents deleterious fusion of… CONTINUE READING
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