Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells.

@article{Rybak2011CharacterizationOS,
  title={Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells.},
  author={Adrian P. Rybak and Lizhi He and Anil B. Kapoor and J C Cutz and Damu Tang},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1813 5},
  pages={683-94}
}
While accumulating evidence demonstrates the existence of prostate cancer stem cells (PCSCs), PCSCs have not been isolated and thoroughly characterized. We report here the enrichment and characterization of sphere-propagating cells with stem-like properties from DU145 PC cells in a defined serum-free medium (SFM). Approximately 1.25% of monolayer DU145 cells formed spheres in SFM and 26% of sphere cells formed secondary spheres. Spheres are enriched for cells expressing prostate basal and… CONTINUE READING
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